Self-driving cars, care robots, apps, software for recruitment procedures, or for use in complex medical diagnostic processes such as MRI scans — it has long been clear that many new technologies in the field of informatics bring both benefits and risks. The ambivalence of new technologies also raises the question of responsibility for the consequences associated with them. The aim of this lecture series is to contribute to this debate by discussing fundamental and application-oriented ethical questions in informatics together with relevant experts. An open discourse is particularly important to us, one in which all arguments surrounding often controversial topics can be heard and evaluated.